11-nor-THC-COOH is the urinary metabolite detected for screening which substance?

11-nor-THC-COOH is the urinary metabolite detected for screening which substance?

• A. Methamphetamine
• B. Cocaine
• C. Cannabis
• D. Benzodiazepines

Answer: (C)

11-nor-THC-COOH is the urinary metabolite used to screen cannabis use. When cannabis is consumed, the body converts delta-9-THC first to 11-hydroxy-THC and then to 11-nor-9-carboxy-THC, which is excreted in urine as 11-nor-THC-COOH. This metabolite is specific to cannabis and remains detectable for days to weeks depending on usage, making it the standard target for initial urine screening (with confirmation by GC-MS or LC-MS/MS). Other drugs listed have different urinary markers, so they would not produce 11-nor-THC-COOH.

11-nor-THC-COOH is the urinary metabolite used to screen cannabis use. When cannabis is consumed, the body converts delta-9-THC first to 11-hydroxy-THC and then to 11-nor-9-carboxy-THC, which is excreted in urine as 11-nor-THC-COOH. This metabolite is specific to cannabis and remains detectable for days to weeks depending on usage, making it the standard target for initial urine screening (with confirmation by GC-MS or LC-MS/MS). Other drugs listed have different urinary markers, so they would not produce 11-nor-THC-COOH.